2026

Zhang I, Herrmann A, Mohammadifar E, Herre F, Multhaup G, Haag R, Maysinger D. Dually Charged Dendrimeric Polyglycerol Modulates Interleukin-33 at Alarmin Receptors in Microglia. ACS Chemical Neuroscience. 2026 May 4. 10.1021/acschemneuro.6c00161.

2025

Ulku I, Ansari FE, Hancock MA, Zhou H, Cagnone G, Joyal JS, Fisher TA, Kennedy TE, Liebsch F, Multhaup G. Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway. Proc Natl Acad Sci. 2025 Nov 4;122(44):e2507450122.

Cervellati C, Trentini A, Zuin M, Mola G, Riccetti R, Manfrinato C, Sergi D, Multhaup G, Zuliani G. BACE-1 and ADAM-10 as Potential Peripheral Biomarkers for Alzheimer’s Disease.

Cervellati C, Trentini A, Rosta V, Passaro A, Brombo G, Renzini C, Multhaup G, Zuliani G. Serum β-secretase 1 (sBACE1) activity in subjective cognitive decline: an exploratory study. GeroScience. 2025 Jun;47(3):4109-20.

2024

Ulku I, Leung R, Herre F, Walther L, Shobo A, Saftig P, Hancock MA, Liebsch F, Multhaup G. Inhibition of BACE1 affected both its Abeta producing and degrading activities and increased Abeta42 and Abeta40 levels at high level BACE1 expression. J Biol Chem. 2024 Jun 27:107510.

2023

Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, Di Spiezio A, Thinakaran G, Saftig P, Multhaup G. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis. Scientific Reports. 2023 Feb 7;13(1):2216.

Maysinger D, Zhang I, Wu PY, Kagelmacher M, Luo HD, Kizhakkedathu JN, Dernedde J, Ballauff M, Haag R, Shobo A, Multhaup G. Sulfated Hyperbranched and linear polyglycerols modulate HMGB1 and morphological plasticity in neural cells. ACS Chemical Neuroscience. 2023 Jan 30;14(4):677-88.

2022

Shobo A, Röntgen A, Hancock MA, Multhaup G. Biophysical characterization as a tool to predict amyloidogenic and toxic properties of amyloid-β42 peptides. FEBS Lett. 2022 Jun;596(11):1401–1411.

Gallwitz L, Schmidt L, Marques AR, Tholey A, Cassidy L, Ulku I, Multhaup G, Di Spiezio A, Saftig P. Cathepsin D: analysis of its potential role as an amyloid beta degrading protease. Neurobiology of Disease. 2022 Dec 1;175:105919.

Maysinger D, Sanader Maršić Z, Gran ER, Shobo A, Macairan JR, Zhang I, Perić Bakulić M, Antoine R, Multhaup G, Bonacic-Koutecky V. Insights into the impact of gold nanoclusters Au10SG10 on human microglia. ACS Chemical Neuroscience. 2022 Jan 26;13(4):464-76.

Shobo A, James N, Dai D, Röntgen A, Black C, Kwizera JR, Hancock MA, Bui KH, Multhaup G. The amyloid-β1–42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution. Journal of Biological Chemistry. 2022 Jan 1;298(1).

2021

Chatterjee P, Tegg M, Pedrini S, Fagan AM, Xiong C, Singh AK, Taddei K, Gardener S, Masters CL, Schofield PR, Multhaup G. Plasma amyloid-beta levels in a pre-symptomatic dutch-type hereditary cerebral amyloid angiopathy pedigree: a cross-sectional and longitudinal investigation. International journal of molecular sciences. 2021 Mar 13;22(6):2931.

13.    Chatterjee P, Fagan AM, Xiong C, McKay M, Bhatnagar A, Wu Y, Singh AK, Taddei K, Martins I, Gardener SL, Molloy MP, Multhaup G, et al. Presymptomatic Dutch-type hereditary cerebral amyloid angiopathy-related blood metabolite alterations. Journal of Alzheimer’s Disease. 2021 Jan 19;79(2):895-903.

Achazi K, Haag R, Ballauff M, Dernedde J, Kizhakkedathu JN, Maysinger D, Multhaup G. Understanding the interaction of polyelectrolyte architectures with proteins and biosystems. Angewandte Chemie International Edition. 2021 Feb 19;60(8):3882-904.

2019

Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, Nitsch RM, Multhaup G, Kulic L. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease. Acta neuropathologica communications. 2019 Dec 3;7(1):194.

Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P. Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression. Nature communications. 2019 May 20;10(1):2240.

Zhong Y, Shobo A, Hancock MA, Multhaup G. Label‐free distribution of anti‐amyloid D‐AIP in Drosophila melanogaster: Prevention of Aβ42‐induced toxicity without side effects in transgenic flies. Journal of Neurochemistry. 2019 Jul;150(1):74-87.

Akerman SC, Hossain S, Shobo A, Zhong Y, Jourdain R, Hancock MA, George K, Breton L, Multhaup G. Neurodegenerative disease-related proteins within the epidermal layer of the human skin. Journal of Alzheimer’s Disease. 2019 May 21;69(2):463-78.

2018

Quadir M, Fehse S, Multhaup G, Haag R. Hyperbranched polyglycerol derivatives as prospective copper nanotransporter candidates. Molecules. 2018 May 26;23(6):1281.

Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM. Dimerization of the cellular prion protein inhibits propagation of scrapie prions. Journal of Biological Chemistry. 2018 May 1;293(21):8020-31.

Schauenburg L, Liebsch F, Eravci M, Mayer MC, Weise C, Multhaup G. APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding. Scientific Reports. 2018 Jan 30;8(1):1916.

Maysinger D, Ji J, Moquin A, Hossain S, Hancock MA, Zhang I, Chang PK, Rigby M, Anthonisen M, Grütter P, Breitner J. Dendritic polyglycerol sulfates in the prevention of synaptic loss and mechanism of action on glia. ACS Chemical Neuroscience. 2018 Feb 21;9(2):260-71.

2017

Dunsing V, Mayer M, Liebsch F, Multhaup G, Chiantia S. Direct evidence of amyloid precursor–like protein 1 trans interactions in cell–cell adhesion platforms investigated via fluorescence fluctuation spectroscopy. Molecular biology of the cell. 2017 Dec 1;28(25):3609-20.

Rao VT, Khan D, Cui QL, Fuh SC, Hossain S, Almazan G, Multhaup G, Healy LM, Kennedy TE, Antel JP. Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions. PloS one. 2017 Aug 8;12(8):e0182372.

Liebsch F, Aurousseau MR, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G. Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. Journal of Biological Chemistry. 2017 Aug 11;292(32):13258-70.

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N. Evidence for heterodimerization and functional interaction of the angiotensin type 2 receptor and the receptor MAS. Hypertension. 2017 Jun;69(6):1128-35.

2016

Prade E, Barucker C, Sarkar R, Althoff-Ospelt G, Lopez del Amo JM, Hossain S, Zhong Y, Multhaup G, Reif B. Sulindac sulfide induces the formation of large oligomeric aggregates of the Alzheimer’s disease amyloid-β peptide which exhibit reduced neurotoxicity. Biochemistry. 2016 Mar 29;55(12):1839-49.

Mayer MC, Schauenburg L, Thompson‐Steckel G, Dunsing V, Kaden D, Voigt P, Schaefer M, Chiantia S, Kennedy TE, Multhaup G. Amyloid precursor‐like protein 1 (APLP1) exhibits stronger zinc‐dependent neuronal adhesion than amyloid precursor protein and APLP 2. Journal of neurochemistry. 2016 Apr;137(2):266-76.

2015

Barucker C, Bittner HJ, Chang PK, Cameron S, Hancock MA, Liebsch F, Hossain S, Harmeier A, Shaw H, Charron FM, Gensler M. Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function. Scientific reports. 2015 Oct 29;5(1):15410.

Multhaup G, Huber O, Buée L, Galas MC. Amyloid precursor protein (APP) metabolites APP intracellular fragment (AICD), Aβ42, and tau in nuclear roles. Journal of Biological Chemistry. 2015 Sep 25;290(39):23515-22.

Prade E, Bittner HJ, Sarkar R, Del Amo JM, Althoff-Ospelt G, Multhaup G, Hildebrand PW, Reif B. Structural mechanism of the interaction of Alzheimer disease Aβ fibrils with the non-steroidal anti-inflammatory drug (NSAID) sulindac sulfide. Journal of Biological Chemistry. 2015 Nov 27;290(48):28737-45.

Barucker C, Sommer A, Beckmann G, Eravci M, Harmeier A, Schipke CG, Brockschnieder D, Dyrks T, Althoff V, Fraser PE, Hazrati LN. Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors. Journal of Alzheimer’s Disease. 2015 Jan 22;44(2):613-24.

2014

Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC. Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta neuropathologica communications. 2014 Jun 5;2(1):61.

Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G. Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription. Journal of Biological Chemistry. 2014 Jul 18;289(29):20182-91.

Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G. Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. Journal of Biological Chemistry. 2014 Jul 1;289(27):19019-30.

Fehse S, Nowag S, Quadir M, Kim KS, Haag R, Multhaup G. Copper transport mediated by nanocarrier systems in a blood–brain barrier in vitro model. Biomacromolecules. 2014 May 12;15(5):1910-9.